| Annotated protein: | Calcium-binding protein 1 (CaBP1). Gene symbol: CABP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JLK7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CABP1 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic actin cytoskeleton (GO:0098885) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Mikhaylova M, et al. "Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines" Neuron. 2018 Mar 7;97(5):1110-1125.e14 PMID:29478916 |
| Figure(s): | Fig.4, 5, 6, 7, 8 |
| Annotation description: | Fig.4: "Effect of Caldendrin Overexpression and Deletion on Morphology of Dendritic Spines in Hippocampal Neurons" Fig.5: "shRNA Knockdown of Caldendrin or Cortactin Abolishes BDNF-Induced Changes in Spine Density and Spine Size Potentiation" Fig.6: "Caldendrin Regulates Actin and Cortactin Turnover in Spines" Fig.7: "Lack of Caldendrin Causes Misarrangement of Spinous F-Actin at the Nanoscale Level" Fig.8: "Caldendrin-Knockout Mice Show Severely Diminished CA1 LTP and Impaired Performance in Hippocampus-Specific Memory Task due to Impaired Activity-Dependent Spine Stabilization" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Super resolution Confocal Field recordings FRET |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2871 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |