| Annotated protein: | CPG2 protein. Gene symbol: SYNE1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63128 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNE1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Loebrich S, et al. "Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2" Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4548-56 PMID:24191017 |
| Figure(s): | Fig.2, 3, 4, 5 |
| Annotation description: | Fig.2: "Association with F-actin anchors CPG2 in dendritic spines" Fig.3: "Binding to F-actin is attenuated by protein sequence directly preceding the F-actin association domain" Fig.4: "PKA phosphorylates CPG2 in the F-actin association domain in vivo. " Fig.5: "PKA phosphorylation is required for actin binding in vivo" |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | source paper for commonly used CPG2 construct, features (among others) EM evidence @ PMID:15541315 |
| SynGO annotation ID: | 2906 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |