| Annotated protein: | Catenin delta-2. Gene symbol: CTNND2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35116 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTNND2 |
| Ontology domain: | Biological Process |
| SynGO term: | structural constituent of postsynaptic density (GO:0098919) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Silverman JB, et al. "Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes" J Neurosci. 2007 Aug 8;27(32):8505-16 PMID:17687028 |
| Figure(s): | Fig.1, 5, 6, 7 |
| Annotation description: | Conclusion: CTNND2; NPRAP is a protein that structurally couples AMPARs to cadherins via the GRIP1 (possibly GRIP2) proteins. Fig.1: "Formation of GluR2-ABP/GRIP-NPRAP-cadherin complexes in vitro and in vivo." Fig.5: "PSD enrichment and interaction of endogenous NPRAP with N-cadherin and the scaffolding proteins ABP, GRIP, and PSD-95 in brain and synaptosomal fractions." Fig.6: "Exogenous NPRAP recruits ABP to spines of cultured neurons dependent on the PDZ binding site" Fig.7: "Dominant-negative NPRAP constructs decrease cell surface endogenous AMPAR" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2967 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |