Annotated protein:Catenin delta-2. Gene symbol: CTNND2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35116
antibody wiki:
SynGO gene info:SynGO data @ CTNND2
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Silverman JB, et al. "Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes" J Neurosci. 2007 Aug 8;27(32):8505-16 PMID:17687028
Figure(s):Fig.1, 5, 6, 7
Annotation description:Conclusion: CTNND2; NPRAP is a protein that structurally couples AMPARs to cadherins via the GRIP1 (possibly GRIP2) proteins.

Fig.1: "Formation of GluR2-ABP/GRIP-NPRAP-cadherin complexes in vitro and in vivo."

Fig.5: "PSD enrichment and interaction of endogenous NPRAP with N-cadherin and the scaffolding proteins ABP, GRIP, and PSD-95 in brain and synaptosomal fractions."

Fig.6: "Exogenous NPRAP recruits ABP to spines of cultured neurons dependent on the PDZ binding site"

Fig.7: "Dominant-negative NPRAP constructs decrease cell surface endogenous AMPAR"

Note: a term "NT localization to PSD" would have made sense here, but the data in Fig.7 does not really allow for this.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Western blot
Biochemical fractionation (generic)
IP + WB/MSMS
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2968
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology