| Annotated protein: | Synapsin-1 (Synapsin I). Gene symbol: SYN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88935 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle cycle (GO:0098693) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Ryan TA, et al. "Synaptic vesicle recycling in synapsin I knock-out mice" J Cell Biol. 1996 Sep;134(5):1219-27 PMID:8794863 |
| Figure(s): | Fig. 2 |
| Annotation description: | In this paper, the authors used the fluorescence imaging of FM1-43 dye to investigate the neurotransmitter release in wild type and Synapsin I KO mice. They showed that the number of vesicles that release their content and the total recycling vesicle pool is reduced by 60-70%. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| Additional literature: | In this paper, the interaction of synapsin 1 with F-actin and its role in the polymerization of actin filaments were investigated in vitro. The authors demonstrated that synapsin I binds to actin in vitro, which supports the idea that synapsin 1 is involved in clustering of synaptic vesicles at the presynaptic terminal. Also, phosphorylation of synapsin I may be involved in regulating the translocation of synaptic vesicles to their sites of release. @ PMID:3104800 In this paper, using a synapsin 1 null mouse model, it was shown that the density of synaptic vesicles in the nerve terminal, as well as the size of them, is reduced. @ PMID:8557745 |
| SynGO annotation ID: | 318 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |