Annotated protein:	Cortactin-binding protein 2 (CortBP2). Gene symbol: CTTNBP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q2IBD4
antibody wiki:	search antibodypedia...
SynGO gene info:	SynGO data @ CTTNBP2
Ontology domain:	Biological Process
SynGO term:	regulation of synapse organization (GO:0050807)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Chen YK, et al. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance" J Neurosci. 2012 Jan 18;32(3):1043-55 PMID:22262902
Figure(s):	Figure 4, 5, 7, Table 1
Annotation description:	CTTNBP2 regulates dendritic spine morphology and synaptic activity (Fig 4) by stabilizing the actin actin-binding protein cortactin (CTTN; SynGO ID 223) at synapses (Fig 5 and 7). 28/3/2017 Pim The referenced figures show an effect on synapse density. The authors state that CTTNBP2 afects both formation of new synapses and the maintenance of exisiting ones: 1. "Therefore, the experiments performed during DIV 12-18 favor a role of CTTNBP2 in **spinogenesis**" 2. "These data suggest that CTTNBP2 is likely also involved in the **maintenance of dendritic spines**" The approporiate terms for these processed would be: ad 1: 'regulation of synapse assembly (GO:0051963)' ad 2: 'maintenance of synapse structure (term not in SynGO)' One can also use a single more general term to capture both phenomena: 'regulation of synapse organization (GO:0050807)'
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	RNAi / shRNA Over-expression
Evidence tracking, Experiment Assay:	Confocal Fluorescence recovery after photobleaching (FRAP) Whole-cell patch clamp IP + WB/MSMS
Annotator(s):	Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758)
Lab:	Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
SynGO annotation ID:	360
Dataset release (version):	20231201
View annotation as GO-CAM model: