Annotated protein:Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1). Gene symbol: MAPK3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q63844
antibody wiki:
SynGO gene info:SynGO data @ MAPK3
Ontology domain:Biological Process
SynGO term:modulation of chemical synaptic transmission (GO:0050804)
Synapse type(s):striatum, glutamatergic
Annotated paper:Mazzucchelli C, et al. "Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory" Neuron. 2002 May 30;34(5):807-20 PMID:12062026
Figure(s):Figs 3
Annotation description:Figure 3: Tetanic stimulation of neocortical inputs to saggital slices of nucleus accumbens produced significantly larger LTP in ERK1 mutant mice. Theta-burst stimulation delivered to Schaffer collateral/commissural inputs to CA1 produced significantly less LTP in knockouts, compared to wild-type controls, while tetanic stimulation produced equal magnitude LTP in both ERK1-/- and ERK1+/+ slices. The authors show enhanced ERK2 Signaling in ERK1 mutant brains revealing an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Field recordings
Annotator(s):Ruud Toonen (ORCID:0000-0002-9900-4233)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:3649
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology