| Annotated protein: | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (HECT-type ubiquitin transferase E3A) (Oncogenic protein-associated protein E6-AP). Gene symbol: UBE3A. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08759 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ UBE3A |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sun J, et al. "UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis" Cell Rep. 2015 Jul 21;12(3):449-61 PMID:26166566 |
| Figure(s): | Figure 5, 6 |
| Annotation description: | Figure 4: Ube3A ubiquitinates small conductance potassium channels (SK) regulating its cell surface expression. Figure 5: Reversal of LTP impairment in Ube3A null (AS) mice by apamin, an SK2 channel blocker shows that Ube3A depletion leads to higher membrane expression of SK2 leading to LTP impairments. Figure 6: TBS failed to induce LTP in hippocampal slices from AS mice. 19/6/2018 Pim - I find no data in the paper that places the SK2 endocytosis in the pre or postsynaptic compartment. The annotation of pre/postsynaptic endocytosis of the ion channel will not be made (and new terms implemented). Instead the annotation to 'modulation of chemical synaptic transmission (GO:0050804)' will be made to capture the effects on LTP. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3729 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |