| Annotated protein: | Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A). Gene symbol: STX1A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P32851 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX1A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Hussain S, et al. "SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus" Front Mol Neurosci. 2016 Feb 5;9:10 PMID:26903802 |
| Figure(s): | Figures 3 5 &6 |
| Annotation description: | Figures 3A,B,D,E: Presynaptically, the highest density of syntaxin-1 immunoreactivity in the presynaptic compartment was located at the plasma membrane of the AZ. Many gold particles were also observed attached to presynaptic vesicles. Figure 5 shows quantification of immune-gold particles at presynapse. 19/6/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3749 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |