| Annotated protein: | Dystrophin. Gene symbol: DMD. Taxonomy: Mus musculus (Mouse). Uniprot ID: P11531 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DMD |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization (GO:0099572) |
| Synapse type(s): | superior cervical ganglion (SCG) |
| Annotated paper: | De Stefano ME, et al. "Dystrophin and its isoforms in a sympathetic ganglion of normal and dystrophic mdx mice: immunolocalization by electron microscopy and biochemical characterization" Neuroscience. 1997 Sep;80(2):613-24 PMID:9284362 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Immunoreactivity of dystrophin and dystrophin isoforms was widely distributed throughout the ganglionic neurons. About 60-65% of more than 100 observed postsynaptic specializations are immunopositive (Fig. 3A,B). Although our observations were conducted at the surface of the specimens, within the range of antibody penetration, the risk of false negatives is still high, especially for structures as thin as these ganglionic postsynaptic densities, and the above percentage may represent an underestimate. Presynaptic boutons were never labelled (Fig. 3A,B)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Also found in PSD preps of brain. @ PMID:1454857 |
| SynGO annotation ID: | 3788 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |