| Annotated protein: | Oligophrenin-1. Gene symbol: OPHN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0CAX5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPHN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle endocytosis (GO:1900242) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Nakano-Kobayashi A, et al. "The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1" Curr Biol. 2009 Jul 14;19(13):1133-9 PMID:19481455 |
| Figure(s): | Fig. 1, 2, 3, 4 |
| Annotation description: | Fig.1: "OPHN1 Is Important for Efficient SV Endocytosis" Fig.2: "Presynaptic OPHN1 Knockdown Augments Short-Term Synaptic Depression" Fig.3: "Interaction of OPHN1 with Endophilin A1 (Endo A1)" Fig.4: "OPHN1/Endophilin A1 Interaction and OPHN1 Rho-GAP Activity Are Important for Efficient SV Endocytosis" Note: Endophilin is also known to be involved in 'regulation of synaptic vesicle endocytosis (GO:1900242)'. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Optical physiology IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3804 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |