| Annotated protein: | Neurobeachin (Lysosomal-trafficking regulator 2). Gene symbol: NBEA. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EPN1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NBEA |
| Ontology domain: | Biological Process |
| SynGO term: | synapse organization (GO:0050808) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Niesmann K, et al. "Dendritic spine formation and synaptic function require neurobeachin" Nat Commun. 2011 Nov 22;2:557 PMID:22109531 |
| Figure(s): | Fig.1, 2, 3, 4 |
| Annotation description: | Fig.1: "Nbea knockout neurons in culture fail to develop a normal number of dendritic spines." Fig.2: "Selective reduction of axo-spinous synapses in brains of heterozygous Nbea-mutant mice" Fig.3: "Organization of the postsynaptic compartment in absence of Nbea." Fig.4: "Nbea deletion affects postsynaptic currents in cultured knockout neurons and heterozygous brain slices." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3833 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |