| Annotated protein: | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2). Gene symbol: LPAR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61794 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LPAR1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | medulla, GABAergic |
| Annotated paper: | Garcia-Morales V, et al. "Membrane-derived phospholipids control synaptic neurotransmission and plasticity" PLoS Biol. 2015 May 21;13(5):e1002153 PMID:25996636 |
| Figure(s): | Fig.6, 7 |
| Annotation description: | Fig.6: "LPA induces GABAAergic STD and GABAAγ2 dephosphorylation via postsynaptic LPA1-RhoA/ROCK-CaN signaling" - "Multiple immunolabeling confocal images of the HN from P7 rats showing colocalization between LPA1-ir and gephyrin-ir (top). 3-D reconstruction (bottom) showing that LPA1-ir colocalizes with gephyrin in a SMI32-ir HMN." Fig.7: "LPA induces dephosphorylation and internalization of the GABAAγ2 subunit in a ROCK/CaN-dependent manner" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3865 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |