| Annotated protein: | Tuberin (Tuberous sclerosis 2 protein homolog). Gene symbol: TSC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P49816 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TSC2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yasuda S, et al. "Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex" Sci Rep. 2014 Jun 3;4:5155 PMID:24889507 |
| Figure(s): | Fig.1 |
| Annotation description: | Tsc2+/- hippocampal pyramidal neurons transfected at DIV 21 with EGFP showed immature spines ( more long, thin filopodia) compared the WT. Quantification showed the Tsc2 mutation reduced the width of dendritic protrusions and increased their length. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 3928 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |