| Annotated protein: | Neuronal membrane glycoprotein M6-a (M6a). Gene symbol: GPM6A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q812E9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPM6A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
| Figure(s): | Suppl. Table S1 (mmc2.xlsx), Suppl. Table S5 (mmc4.xlsx) |
| Annotation description: | Average enrichment of Neuronal membrane glycoprotein M6-a in docked synaptic vesicles is >4.3 fold (Table S1). Enriched in glutamatergic vs. GABAergic terminals about 3.3 fold (Table S5) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Immunoelectron microscopic localization of the M6a antigen in rat brain (Fig. 5). Localization of immunoreactivity in presynaptic boutons of cerebellar parallel fibres and cerebral cortex. No immunoreactivity is observed on the postsynaptic side. @ PMID:10447243 |
| SynGO annotation ID: | 413 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |