Annotated protein:Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A). Gene symbol: STXBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08599
antibody wiki:
SynGO gene info:SynGO data @ STXBP1
Ontology domain:Cellular Component
SynGO term:presynaptic active zone cytoplasmic component (GO:0098831)
Synapse type(s):cerebellum
Parallel fibre (cerebellum -> Purkinje-cell)
Annotated paper:Siddig S, et al. "Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones" Sci Adv. 2020 Apr 15;6(16):eaay7193 PMID:32494600
Figure(s):Fig 1, 2 ,4 and 5
Annotation description:dSTORM imaging of granule cell synapses with the dendritic spines of Purkinje cells show co-localization of mGlur4 microdomains with Munc18-1 (Fig 5) and Bassoon (Fig 4).

antibody KO verified: monoclonal mouse antibody against Munc18-1 (catalog no. 116011) were from Synaptic Systems (Göttingen, Germany).

28/01/2021 Dnyanada: The paper shows that mGlur4 closely associates with active zone marker Bassoon. It also shows that Munc18-1 is localised with mGlur4.
SynGO ID:82 (PMID:17110441) shows that Munc18-1 plays an essential role in synaptic vesicle priming. Based on all these, the term "presynaptic active zone cytoplasmic component".
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Super resolution
Annotator(s):Ruud Toonen (ORCID:0000-0002-9900-4233)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:4170
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology