| Annotated protein: | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1). Gene symbol: CYFIP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TMB8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CYFIP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | De Rubeis S, et al. "CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation" Neuron. 2013 Sep 18;79(6):1169-82 PMID:24050404 |
| Figure(s): | Fig.S1A |
| Annotation description: | Immuno-EM detects the protein in dendrites, spines, and also axons. Fig. S1G supports the EM findings by biochemical fractionation of mouse brain: the protein is mostly found (by Western blot) in the post-synaptic and pre-synaptic fractions. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Detected by Western blot in synaptosome preparations from total mouse brain (Three- to 4-week-old C57BL/6; Fig. 4). @ PMID:11438699 Detected by Western blot in synaptosome preparations from cortex of 3-week old mice (Fig. 6B, 6D). @ PMID:18805096 Detected by immunofluorescence in primary rat hippocampal neurons (DIV 17-20; Fig.1A; 1C; 1F ). Confirmed by overexpression of GFP-tagged CYFIP1. @ PMID:24667445 |
| SynGO annotation ID: | 435 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |