| Annotated protein: | Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin). Gene symbol: ICAM5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q60625 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ICAM5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Kelly EA, et al. "Subcellular localization of intercellular adhesion molecule-5 (telencephalin) in the visual cortex is not developmentally regulated in the absence of matrix metalloproteinase-9" J Comp Neurol. 2014 Feb 15;522(3):676-88 PMID:23897576 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | Figure 2. immunoperoxidase labeling of ICAM-5 in WT P14 and P28 mouse visual cortex shows localization to dendritic spines and putative filopodia, as well as dendrites and (to a lesser extend) glia. Figure 3. "The immunogold reactivity for ICAM-5 also showed the expected distribution in neuronal cell bodies, dendrites, dendritic protrusions and glial profiles, including Iba-1 labeled microglial elements (Figure 3A-D). As the immunogold labeling affords a precise localization, this analysis also revealed that ICAM-5 predominantly localizes to the plasma membrane of neuronal and glial profiles" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4642 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |