| Annotated protein: | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2). Gene symbol: ROCK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70336 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ROCK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone (GO:0048786) |
| Synapse type(s): | cerebellum Neuro-muscular junction |
| Annotated paper: | Iizuka M, et al. "Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues" Cell Struct Funct. 2012;37(2):155-75 PMID:22986902 |
| Figure(s): | Figure 9, 10 |
| Annotation description: | Figure 9u-x. immunogold labeling in mouse cerebellum; "ROCK2 IR was observed at synapses in the cerebellar molecular layer (Fig. 9U-X; U, black arrows, near active zone; V, at presynapse only; W, at both pre- and postsynapse; X, at postsynapse only)." Figure 10e. immunogold labeling in mouse motor nerve NMJ; "Black arrows denote the ROCK2 IR localized at active zones of nerve terminals in neuromuscular junctions" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4651 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |