| Annotated protein: | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin). Gene symbol: AP2S1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62744 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP2S1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic vesicle (GO:0008021) |
| Annotated paper: | Taoufiq Z, et al. "Hidden proteome of synaptic vesicles in the mammalian brain" Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596 PMID:33376223 |
| Figure(s): | Dataset S1 |
| Annotation description: | AP2S1 was detected in SV biochemical fractions, and enriched as compared to the P2 fraction. This protein was also detected in SV biochemical fractions in Takamori et al. 2006 (PMID: 17110340). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) Mass-spectrometry |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | NP_075241 protein was identified in SV biochemical fractions @ PMID:17110340 |
| SynGO annotation ID: | 4763 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |