| Annotated protein: | Autophagy protein 5 (APG5-like). Gene symbol: ATG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99J83 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATG5 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Kallergi E, et al. "Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice" Nat Commun. 2022 Feb 3;13(1):680 PMID:35115539 |
| Figure(s): | Fig. 7 |
| Annotation description: | The paper demonstrates that autophagy is required for LTD at Schaffer collateral synapses. Fig. 7 shows that both conditional knockout and shRNA knockdown of ATG5 disrupts the maintenance of LTD induced by either low-frequency stimulation, or the application of NMDA, or of the group 1 mGluR agonist DHPG. ATG5-cKO also leads to altered cognitive flexibility (Fig. 8). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4901 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |