| Annotated protein: | Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1). Gene symbol: CRHR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P35347 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CRHR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chen Y, et al. "Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress" Neuroscience. 2004;126(3):533-40 PMID:15183503 |
| Figure(s): | Figure 3 |
| Annotation description: | "Using the finer resolution afforded by EM (Fig. 3), CRF1-immunogold particles were primarily concentrated at asymmetric PSDs of dendritic spines, typical sites for the location of excitatory synapses. This localization of the receptor is consistent with a potentiating role of CRH on hippocampal neurotransmission." Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5092 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |