| Annotated protein: | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64). Gene symbol: DPYSL2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P47942 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DPYSL2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhang J, et al. "Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines" Brain Res Bull. 2018 May;139:21-30 PMID:29425794 |
| Figure(s): | Figures 1-8 |
| Annotation description: | - CRMP2 (DPYSL2) promotes the dendritic spine maturation in cultured hippocampal neurons. - Dephosphorylation of CRMP2 at Thr514 further promotes the dendritic spine maturation. - DeSUMOylation of CRMP2 at Lys374 also promotes the dendritic spine maturation. - During this process, SUMOylation of CRMP2 is independent of its phosphorylation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | CRMP2 knockout mice exhibits decreased dendritic complexity and mature spine density @ PMID:27249678 |
| SynGO annotation ID: | 5122 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |