| Annotated protein: | Transmembrane protein 108 (Retrolinkin). Gene symbol: TMEM108. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BHE4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TMEM108 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jiao HF, et al. "Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus" Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1177-1182 PMID:28096412 |
| Figure(s): | Figure 1, S2, 4 |
| Annotation description: | Figure 1: TMEM108 was enriched in PSD biochemical fractions from hippocampal tissue. Figure S2: immunofluorescence labeling of flag-TMEM108 in DIV13 hippocampal neurons showed localization to dendritic spines. Figure 4c: TMEM108 puncta colabeled with GFP-GluA2 in spines as well as dendrites. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Biochemical fractionation (generic) Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5181 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |