| Annotated protein: | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP). Gene symbol: SYNGAP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QUH6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNGAP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yang Y, et al. "SynGAP moves out of the core of the postsynaptic density upon depolarization" Neuroscience. 2011 Sep 29;192:132-9 PMID:21736925 |
| Figure(s): | Fig. 3 |
| Annotation description: | Fig. 3 EM microscopy shows SynGAP postsynaptic localization. Literal "The great majority (>90%) of synaptic profiles labeled for SynGAP in the PSD complex in dissociated hippocampal cultures under basal conditions." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | Figure 4. SynGAP Is Synaptically Localized Literal "Double labeling the hippocampal neu- rons with antibodies against SynGAP and the synaptic marker protein synaptophysin demonstrated that SynGAP is specifically localized to synapses" Fig. 5a,b SynGAP Is Specifically Localized at Excitatory Synapses Literal "SynGAP was indeed colocalized with PSD-95 (Figure 5A), provid- ing additional evidence that SynGAP is associated with PSD-95. @ PMID:9581761 |
| SynGO annotation ID: | 519 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |