| Annotated protein: | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3). Gene symbol: SHANK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QX74 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SHANK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Boeckers TM, et al. "Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density" J Neurosci. 1999 Aug 1;19(15):6506-18 PMID:10414979 |
| Figure(s): | Fig. 3E,F Fig.4 |
| Annotation description: | Fig.3E,F Shank2 is associated with the PSD Literal "labeling is relatively weak in dendrites (d), enhanced toward dendritic spines (sp), and very strong at PSDs (arrowheads, arrows). " Fig 4 Shank2 is synaptically localized Literal "Figure 4A,B illustrates the punctate distribution and close apposition of ProSAP1-immunoreactive structures and the presynaptic cytomatrix protein Bassoon. The virtually complementary localization of ProSAP1 and the synap- tic vesicle protein synaptophysin or Bassoon at mossy fiber bou- tons of the CA3 region can be seen in Figure 4C,D." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 522 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |