Annotated protein:Adenylyl cyclase-associated protein 1 (CAP 1). Gene symbol: CAP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P40124
antibody wiki:
SynGO gene info:SynGO data @ CAP1
Ontology domain:Biological Process
SynGO term:modification of postsynaptic actin cytoskeleton (GO:0098885)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Heinze A, et al. "Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology" Cell Mol Life Sci. 2022 Oct 20;79(11):558 PMID:36264429
Figure(s):Figure 2, 3
Annotation description:Figure 2: Reduced spine density and increased spine size in CAP1-KO neurons.

Figure 3: CAP1 controls actin turnover and F-actin distribution in spines.
"Hence, our data revealed an altered F-actin distribution within CAP1-KO spines, suggesting a role for CAP1 in organizing the postsynaptic actin cytoskeleton. Interestingly, F-actin disorganization was associated with an altered distribution of key PSD proteins. Together, we identified CAP1 as a novel regulator of the postsynaptic actin cytoskeleton relevant for both actin dynamics and F-actin organization."

Figure 4: Helical folded domain and CARP domain are relevant for CAP1 function in spines.

Figure 7: CAP1 and cofilin1 are functionally interdependent in spines.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
IP + WB/MSMS
Super resolution
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5380
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology