| Annotated protein: | Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6). Gene symbol: SCN8A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O88420 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SCN8A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | neocortex, glutamatergic Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Caldwell JH, et al. "Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses" Proc Natl Acad Sci U S A. 2000 May 9;97(10):5616-20 PMID:10779552 |
| Figure(s): | Fig. 4A,C |
| Annotation description: | Nav1.6 sodium channel located in the presynaptic membrane 6/3/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 546 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |