| Annotated protein: | Alsin (Amyotrophic lateral sclerosis 2 protein homolog). Gene symbol: ALS2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q920R0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ALS2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lai C, et al. "Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking" J Neurosci. 2006 Nov 8;26(45):11798-806 PMID:17093100 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 1, 2: Alsin (ALS2) interacts with GRIP1 and both proteins co-localize at the postsynapse. Figure 4: Increased ratio of synaptic GluR2-lacking AMPARs versus GluR2-containing AMPARs in ALS2 -/- cortical neurons. Figure 5: Decreased presentation of GluR2 at the plasma membrane of ALS2 -/- cortical neurons after AMPA treatment. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Western blot IP + WB/MSMS Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5473 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |