| Annotated protein: | Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Sodium/hydrogen exchanger) (Solute carrier family 9 member 6). Gene symbol: SLC9A6. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZJ86 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC9A6 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Annotated paper: | Lee U, et al. "SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses" Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2011371118 PMID:33372133 |
| Figure(s): | Figure 2, S1 |
| Annotation description: | Figure 1, S1: TM2-2/3-TM3 domain of SCAMP5 directly interacts with the C-terminal region of NHE6 (SLC9A6) Figure 2, S2: Confocal imaging of immunolabeled NHE6 showed overlap with synaptophysin (SYP), VAMP2 and SCAMP5 in cultured rat hippocampal neurons with NHE6 and SCAMP5. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5540 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |