| Annotated protein: | Protein unc-13 homolog A (Munc13-1). Gene symbol: UNC13A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q4KUS2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ UNC13A |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle exocytosis (GO:0016079) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Augustin I, et al. "Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles" Nature. 1999 Jul 29;400(6743):457-61 PMID:10440375 |
| Figure(s): | Figure 1 and Figure 2 |
| Annotation description: | First description of the Munc13-1 knock out mouse using electrophysiology in autistic mouse hippocampal and stratal neurons. Figure 1 shows a 90% reduction in glutamatergic synaptic transmission. GABAergic transmission id not impaired. Figure 2 shows that the impaired glutamatergic neurotransmission results from a decrease in the size of the readily releasable vesicle pool, assessed by sucrose application. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | C.elegans UNC-13 mediates SV docking. @ PMID:16885217 |
| SynGO annotation ID: | 559 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |