| Annotated protein: | Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein). Gene symbol: NCS1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62168 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCS1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | striatum |
| Annotated paper: | Kabbani N, et al. "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor" J Neurosci. 2002 Oct 1;22(19):8476-86 PMID:12351722 |
| Figure(s): | Figure 4f,g |
| Annotation description: | NCS-1 is found in dendritic shafts and spines. Pre-immbedding immunolabeling of NCS-1 in striatum brain slices from rat. The NCS-1 signal was enhanced by a DAB reaction. No KO control or antibody verifications. The images show labeling for NCS-1 in spines and dendritic shafts. No quantifications. DAB signal may diffuse to a rather large distance from the primary antibody, making the spatial resolution of such information difficult to interpret, hence the annotation to 'postsynaptic cytosol' . |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 709 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |