| Annotated protein: | Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9). Gene symbol: SLC6A9. Taxonomy: Mus musculus (Mouse). Uniprot ID: P28571 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A9 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter uptake (GO:0001504) |
| Annotated paper: | Liu QR, et al. "Cloning and expression of a glycine transporter from mouse brain" FEBS Lett. 1992 Jun 29;305(2):110-4 PMID:1618338 |
| Figure(s): | Figure 2, 5, 6 |
| Annotation description: | Description of the GlyT1 knockout. Figure 2 illustrates [3H]Glycine Uptake in P2 membranes from brainstem/spinal cord mixed tissue and forebrain tissue from newborn mice. The figure shows a 70-80% reduction in [3H]Glycine Uptake in the knockout animals compared with the WT animals in both samples. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Transmembrane transport assay |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | Description of the GlyT1 knockout. Figure 2 illustrates [3H]Glycine Uptake in P2 membranes from brainstem/spinal cord mixed tissue and forebrain tissue from newborn mice. The figure shows a 70-80% reduction in [3H]Glycine Uptake in the knockout animals compared with the WT animals in both samples. @ PMID:14622582 |
| SynGO annotation ID: | 742 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |