| Annotated protein: | Cannabinoid receptor 1 (CB-R) (CB1) (Brain-type cannabinoid receptor). Gene symbol: CNR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P47746 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Hebert-Chatelain E, et al. "A cannabinoid link between mitochondria and memory" Nature. 2016 Nov 24;539(7630):555-559 PMID:27828947 |
| Figure(s): | Figure 1E |
| Annotation description: | Immunogold staining of CB1 receptors in the CA1 hippocampal region shows plasma membrane localized CB1 receptors. That staining is lost in CB1 knockout animals. Yellow arrows indicate plasma-membrane CB1 receptors. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| Additional literature: | CB1 is present in both GABAergic and glutamatergic terminals in CA1 in the hippocampus. This is shown using conditional mutant mice lacking CB1 either in glutamatergic (Glu-CB1?/?) or in GABAergic (GABA-CB1?/?) neurons. @ PMID:22388959 Immuno-EM showing CB1 localization to the presynaptic membrane in hippocampal, cerebellar ctx and purkinje cell terminals. @ PMID:16540577 |
| SynGO annotation ID: | 807 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |