| Annotated protein: | Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A). Gene symbol: STXBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08599 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STXBP1 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle priming (GO:0016082) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Toonen RF, et al. "Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size" Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18332-7 PMID:17110441 |
| Figure(s): | fig 1b, 2c-d and 3b-c |
| Annotation description: | Lower or higher expression of Munc18-1, using either munc18-1 null heterozygous neurons or acute over expression of the protein had parallel effects on the pool of releasable vesicles |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 82 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |