Annotated protein:Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A). Gene symbol: STXBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08599
antibody wiki:
SynGO gene info:SynGO data @ STXBP1
Ontology domain:Biological Process
SynGO term:synaptic vesicle priming (GO:0016082)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Toonen RF, et al. "Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size" Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18332-7 PMID:17110441
Figure(s):fig 1b, 2c-d and 3b-c
Annotation description:Lower or higher expression of Munc18-1, using either munc18-1 null heterozygous neurons or acute over expression of the protein had parallel effects on the pool of releasable vesicles
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:82
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology