Annotated protein:Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A). Gene symbol: STXBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08599
antibody wiki:
SynGO gene info:SynGO data @ STXBP1
Ontology domain:Cellular Component
SynGO term:presynaptic cytosol (GO:0099523)
Synapse type(s):hippocampus
Annotated paper:Cijsouw T, et al. "Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner" J Cell Biol. 2014 Mar 3;204(5):759-75 PMID:24590174
Figure(s):fig 4a-g
Annotation description:Using GFP knock-in mice, the authors show that munc18-1 accumulates in boutons/nerve terminals and collocalizes with the vesicle cluster. In FRAP experiments, most of the protein was found to be in the mobile fraction (60%).
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Microscopy (generic)
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:83
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology