| Annotated protein: | Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A). Gene symbol: STXBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08599 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STXBP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of presynaptic membrane (GO:0098888) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Cijsouw T, et al. "Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner" J Cell Biol. 2014 Mar 3;204(5):759-75 PMID:24590174 |
| Figure(s): | Fig 4a-g |
| Annotation description: | Using GFP knock-in mice, the authors show that munc18-1 accumulates in boutons/nerve terminals and collocalizes with the vesicle cluster. In FRAP experiments, a significant fraction of the protein was found to be in the immobile fraction (40%), probably via binding to syntaxin (half of the immobile fraction) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Microscopy (generic) |
| Annotator(s): | Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 84 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |