| Annotated protein: | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2). Gene symbol: ATP2B2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P11506 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATP2B2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | brain, glutamatergic brain, GABAergic |
| Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
| Figure(s): | Table S1 (Document: mmc2.xlsx) |
| Annotation description: | PMCA2 is highly enriched in docked vesicles/active zone membrane fraction relative to free SV fraction. Similar ratio found for PMCA1 in the same paper. 18/01/2017 Pim Note - Because enriched in AZ and not in free SV AT2B2 is presumably localized to the AZ membrane, not in SVs. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 88 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |