Annotated protein:Neurexin-1-beta (Neurexin I-beta). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DI97
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Biological Process
SynGO term:regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (GO:0150036)
Synapse type(s):neocortex
Annotated paper:Anderson GR, et al. "beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling" Cell. 2015 Jul 30;162(3):593-606 PMID:26213384
Figure(s):Figs. 3, 4
Annotation description:Neurexin-1beta without an insert in splice site 4 (SS4-) regulates mEPSC frequency in cultured cortical neurons. Fig. 3 shows that this isoform rescues the decrease in mEPSC frequency that occurs in cultured triple neurexin-1/2/3beta KO neurons.

Fig. 4 shows that the decrease in mEPSC frequency in absence of all beta-neurexins is correlated with an increase in endocannabinoid signaling that originates in the postsynaptic neurons. This indicates that the abovementioned presynaptic neurexin-1beta rescue of excitatory miniature release may involve a regulation of postsynaptic endocannabinoid signaling.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Electrophysiology (generic)
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Additional literature:This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional effects of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659
SynGO annotation ID:895
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology