Annotated protein:Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CS84
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Biological Process
SynGO term:regulation of synaptic vesicle cycle (GO:0098693)
Synapse type(s):Schaffer collateral synapse (CA3->CA1)
Annotated paper:Etherton MR, et al. "Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments" Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17998-8003 PMID:19822762
Figure(s):Figs. 1, 2
Annotation description:Deletion of Neurexin-1alpha reduces spontaneous excitatory synaptic transmission (Fig.1), and Neurexin-1alpha KO mice have decreased evoked excitatory synaptic strength (Fig. 2). The data are consistent with a presynaptic loss of synaptic strength in absence of this Neurexin isoform.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Electrophysiology (generic)
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Additional literature:This study is in agreement with the finding that Neurexin-1/2/3 alpha triple KO mice exhibit a presynaptic loss of synaptic strength. @ PMID:12827191

This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional roles of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659
SynGO annotation ID:898
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology