| Annotated protein: | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3). Gene symbol: ATP1A3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P06687 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATP1A3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cochlea |
| Annotated paper: | McLean WJ, et al. "Distribution of the Na,K-ATPase alpha subunit in the rat spiral ganglion and organ of corti" J Assoc Res Otolaryngol. 2009 Mar;10(1):37-49 PMID:19082858 |
| Figure(s): | Figure 3D-F |
| Annotation description: | The paper studies the distribution of NKAα1 and NKAα3 in the rat spiral ganglion and in the organ of Corti Figure 3D-E demonstrates membrane staining for NKAα3 directly surrounding cytoplasmatic Neurofilament 200, an intermediate filament enriched in the cytoplasm of both types I and II spiral ganglion somata and processes. NKAα3 immunoreactivity is localized to the cell membranes and bouton-shaped endings of the NF200-expressing type I afferent terminals. These staining support a postsynaptic membrane localization of the NKAα3. 19/8/2017 Pim - Localization to the plasma membrane not annotated because not shown in the experimental data. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | The neuronal Na+,K+-ATPase (?3 isoform) was detected in the postsynaptic region of the spine (n cultures of striatal neurons) using super-resolution microscopy. @ PMID:21272290 |
| SynGO annotation ID: | 905 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |