| Annotated protein: | Contactin-5 (Neural recognition molecule NB-2). Gene symbol: CNTN5. Taxonomy: Mus musculus (Mouse). Uniprot ID: P68500 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNTN5 |
| Ontology domain: | Biological Process |
| SynGO term: | presynapse assembly (GO:0099054) |
| Synapse type(s): | spinal cord, GABAergic |
| Annotated paper: | Ashrafi S, et al. "Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord" Neuron. 2014 Jan 8;81(1):120-9 PMID:24411736 |
| Figure(s): | Fig. 2 |
| Annotation description: | Fig 2: Proprioceptive sensory neurons that synapse onto motor neurons in the spinal cord receive axo-axonic inputs from GABAergic inhibitory interneurons or GABApre neurons. Loss of NB-2 resulted in a decrease of GABApre boutons onto sensory presynapses. 12/10/2017 Pim - The study uses a general Contactin-5/NB-2 KO making the site of action (pre/postsynaptic) unclear. However, in Fig.1 the authors show that Contactin-5/NB-2 is only expressed by proprioceptive sensory neurons and not by motorneurons. The site of action or Contactin-5/NB-2 in synapse organization must therefore be presynaptic. In Fig.2 a positive correlational relationship between level of presynaptic Contactin-5/NB-2 expression and the number of boutons in line with this idea. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 973 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |