Annotated protein:Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle). Gene symbol: MYO5A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QYF3
antibody wiki:
SynGO gene info:SynGO data @ MYO5A
Ontology domain:Cellular Component
SynGO term:postsynaptic actin cytoskeleton (GO:0098871)
Synapse type(s):hippocampus, glutamatergic
Schaffer collateral synapse (CA3->CA1)
Annotated paper:Correia SS, et al. "Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation" Nat Neurosci. 2008 Apr;11(4):457-66 PMID:18311135
Figure(s):Fig. 2, 4c,d,f
Annotation description:Myosin Va shows a partial colocalization with GluR1 and GluR2 subunits in primary neuronal cultures (Fig. 2a,b).
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Microscopy (generic)
Electrophysiology (generic)
Biochemical fractionation (generic)
IP + WB/MSMS
Annotator(s):Harold MacGillavry (ORCID:0000-0002-6153-3586)
Casper Hoogenraad (ORCID:0000-0002-2666-0758)
Lab:Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
Additional literature:The heavy chain of Myosin-Va (dilute myosin) was identified in the PSD fraction by mass spectrometry ,

Immunocytochemical localization of myosin-Va in cultured hippocampal neurons shows that it partially colocalizes with PSD-95 at synapses @ PMID:10818142
SynGO annotation ID:984
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology